Microfluidic generation of PEG-b-PLA polymersomes containing alginate-based core hydrogel

Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.

Controlled release polymer vesicles are prepared using hydrolysable diblock copolymers of polyethyleneglycol-poly-l-lactic acid (PEG-PLA) or polyethyleneglycol-polycaprolactone (PEG-PCL). Encapsulation studies with a common anti-cancer agent, doxorubicin, show loading comparable to liposomes. Rates of encapsulant release from the hydrolysable vesicles are accelerated with an increased proportio...

Amphotericin-B-loaded polymersomes formulation (PAMBO) based on (PEG)₃-PLA copolymers: an in vivo evaluation in a murine model.

This paper deals with in vivo evaluation of a new amphotericin-B-loaded polymersomes (PAMBO) formulation in terms of pharmacokinetics, toxicity, tissue distribution profile, and its efficacy in a murine model of disseminated candidiasis. Pharmacokinetic and tissue distribution studies of the PAMBO showed sustained levels of the drug in plasma as well as in target organs which harbor fungal and ...

preparation and characterization of pla-peg-pla tri-block copolymer polymersomes as a novel carrier for lisinopril

Influence of network structure on the degradation of photo-cross-linked PLA-b-PEG-b-PLA hydrogels.

Triblock copolymers of functionalized poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) (PLA-b-PEG-b-PLA) have been widely investigated as precursors for fabricating resorbable polymeric drug delivery vehicles and tissue engineering scaffolds. Previous studies show degradation and erosion behavior of PLA-b-PEG-b-PLA hydrogels to rely on macromer chemistry as well as structural chara...

Microfluidic fabrication of hydrogel microparticles containing functionalized viral nanotemplates.

We demonstrate rapid microfluidic fabrication of hybrid microparticles composed of functionalized viral nanotemplates directly embedded in polymeric hydrogels. Specifically, genetically modified tobacco mosaic virus (TMV) templates were covalently labeled with fluorescent markers or metalized with palladium (Pd) nanoparticles (Pd-TMV) and then suspended in a poly(ethylene glycol)-based solution...